Blood-Brain Barrier and Brain Disposition

Blood-brain barrier disturbances in diabetes-associated dementia

Methods for delivery of drugs across the blood–brain barrier

'Enoch, why dost thou ask me regarding the fragrance of the tree, and why dost thou wish to learn the truth?'

Then I answered him saying: 'I wish to know about everything, but especially about this tree.'

He answered saying: 'This high mountain which thou hast seen, whose summit is like the throne of God, is His throne, where the Holy Great One, the Lord of Glory, the Eternal King, will sit, when He shall come down to visit the Earth.

As for this fragrant tree no mortal is permitted to touch it till the great judgement, when He shall bring consummation.

It shall then be given to the righteous and holy.

Its fruit shall be for food to the elect: it shall be transplanted to the holy place, to the temple of the Lord, Eternal King.

Then shall they rejoice with joy and be glad.

Into the holy place shall they enter.

Its fragrance shall be in their bones.

They shall live a long life on earth, such as thy fathers lived.

In their days shall no plague or calamity touch them.'

CB2 Receptor Activation Inhibits Melanoma Cell Transmigration through the Blood-Brain Barrier

Antitussive effect of WIN 55212-2, a cannabinoid receptor agonist

Cannabinoid Receptor Agonist WIN55,212-2 Ameliorates Hippocampal Neuronal Damage After Chronic Cerebral Hypoperfusion Inhibiting Oxidative Stress and ASK1-p38 Signaling

Cannabinoid WIN 55,212-2 Reduces Delayed Neurologic Sequelae After Carbon Monoxide Poisoning by Promoting Microglial M2 Polarization Through ST2 Signaling

Cannabis synergy and phytocannabinoid-terpenoid entourage effects

Terpenoids are quite potent, and affect animal and even human behaviour when inhaled from ambient air at serum levels in the single digits ng·mL-1

Terpenoids share a precursor with phytocannabinoids, with flavour and fragrance components common to human diets designated GRAS by the US Food and Drug Administration.

Terpenoids are EO components, previously conceived as the quintessential fifth element, 'life force' or spirit, and form the largest group of plant chemicals, with 15–20 000 fully characterized.

Terpenoids, not cannabinoids, are responsible for the aroma of cannabis.

Phytocannabinoids and terpenoids are synthesized in cannabis, in secretory cells inside glandular trichomes that are most highly concentrated in unfertilized female flowers prior to senescence.

Over 100 phytocannabinoids have been identified, but many are artefacts of analysis or are produced in trace quantities that have not permitted thorough investigation.

As observed for cannabinoids, terpenoid production increases with light exposure, but decreases with soil fertility; supported by the glasshouse experience that demonstrates higher yields if plants experience relative nitrogen lack just prior to harvest, favouring floral over foliar growth.

the "entourage effect"

hedonistic thermostat

unique library index

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