Central Sensitization

Infant J&J Motrin Recall of 200,000

Metal contaminated Tylenol for children

Ibuprofen Kills Thousands Each Year

Experience of pain relies on multiple brain pathways

Anti-inflammatory drugs and their effects on cartilage synthesis and renal function

Acetaminophen Blunts Evaluation Sensitivity to Negative and Positive Stimuli

Can autism be triggered by acetaminophen activation of the endocannabinoid system?

"David B. Morris argues convincingly that our culture has embraced a "myth of the two pains": belief mental and physical pain are totally different phenomena.

Common sense and science tell us that they, in fact, can not be separated.

Pain, Morris writes, "is far more than simply or exclusively a medical problem.

It can not be reduced to a mere transaction of the nervous system but also shaped by such powerful cultural forces as gender, religion and social class."

Consider the medieval Catholic self-flagellator, the Iroquois warrior who defined his identity by his defiance of torture, the American evasion of the discomfort.

A culture's response to pain can tell us a great deal.

A corporate or individual's attitude toward pain can be revealing also.

Placing control of pain in the hands of medical experts, making a sharp distinction between "mental" and "physical" pain, using pain to fuel a profit-producing machine: these contributed to the invention of heroin as they did to aspirin."

The Birth of Heroin and the Demonization of the Dope Fiend, Thomas A. Metzger

The Endocannabinoid System, Cannabinoids, and Pain

Vaporized Cannabis Significantly Improves Neuropathic Pain

"It has been estimated conservatively that 16,500 NSAID-related deaths occur among patients with rheumatoid arthritis or osteoarthritis every year in the US.

This figure is similar to the number of deaths from the acquired immunodeficiency syndrome and considerably greater than the number of deaths from multiple myeloma, asthma, cervical cancer, or Hodgkin's disease." - J.S. Hochman, M.D., Executive Director of the National Foundation for the Treatment of Pain 2003

Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs, are drugs with analgesic, antipyretic and anti-inflammatory effects - they reduce pain, fever and inflammation.

More than 100,000 people are hospitalized each year because of adverse reactions to NSAIDs.

More than 15,000 people die, often because of compliciations caused by bleeding or perforated ulcers.

Drugs in this class include ibuprofen (Advil®, Motrin®), diclofenac (Cataflam®, Voltaren®), meloxicam (Mobic®), naproxen (Aleve®, Naprosyn®) and indomethacin (Indocin®).

In addition to digestive-tract damage, NSAIDs can raise blood pressure and increase the risk of heart attack and stroke, as well as injure kidneys and the liver.

NSAIDs and opiates can cause severe hypersensitivity reactions by their cyclooxygenase-inhibiting mechanism or by direct effects on mast cells.

It is possible some cases in these groups are pseudoallergic or IgE-independent anaphylactic reactions, rather than IgE-mediated anaphylactic reactions.

NSAIDs were the most frequent culprits in drug-induced anaphylaxis (47.9% of cases), followed by antibiotics (35.5%) and anaesthetic agents (6.1%)

Saying 'ow' can lessen pain's punch

pain chart

unique library index

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