thing is connected via webs of genetic and epigenetic
mRNAs function as cross-kingdom master regulators of the
fellowship of the biosphere.
Produced by bacteria, fungi, plants, and
animals, mRNAs are capable of surviving digestive and assimilative processes
intact, entering the tissues of organisms, affecting the expression of a wide
range of genes.
"The viral network we have detailed is a snapshot
of the early stages of an epidemic,
before the evolutionary paths of
COVID-19 become obscured by vast numbers of mutations.
It's like catching
an incipient supernova in the act." - Peter Forster
"At the beginning
of an article on the human immunodeficiency virus, (HIV, the putative causal
agent of AIDS that he and others isolated), Dr. Robert C. Gallo observes
without comment that epidemiologists had named the new disease "acquired immune
By attributing the power to name the disorder to
them, Dr. Gallo shows us how prominent a part epidemiology has played in
defining and ordering this "medical mystery."
I examine the role of
epidemiology in characterizing HIV infection.
Faced with a new disease
of unknown origin, epidemiologists and their collaborators constructed, over
time, hypothetical models to explain the disorder in order to contain it.
Prior to the isolation of a putative causal agent, HIV, epidemiologists
played a central role in defining the new syndrome, first developing a
"life-style" model and, later, a model based on hepatitis
Supplanted by virologists and other "bench" scientists working
in laboratories, epidemiologists have continued to define important dimensions
of the disorder and raise disquieting questions.
concerned with defining the natural history of HIV infection, the extent to
which it spread within population groups, factors affecting the spread rates of
Epidemiology, unlike virology, has a strong social dimension
in that it explicitly incorporates perceptions of a population's social
relations, behavioral patterns, and experiences into its explanations of
disease." - Gerald M. Oppenheimer
the Eye of the Storm: The Epidemiological Construction of
|mRNAs are short non-coding
RNA molecules involved in the posttranscriptional epigenetic regulation of gene
Recent data show that mRNAs can be found in body fluids,
and these mRNAs might enter cells giving rise to
a hormone like way of
mRNAs released in body fluids might affect other
individuals, and there are some data of potential cross-species action of
mRNAs wander via the food-chain.
mRNAs may influence gene expression.
mRNA genes, located in the non-protein
coding "dark matter" of the genome, may facilitate interindividual and
cross-species epigenetic communication via information transfer by coded gene
HIV-infected cells persist only for a day or
HTLV is thought to replicate by promoting proliferation of infected
"Assume about 10 years between HIV infection and diagnosis of AIDS."
The simian foamy virus (SFV), a spumavirus, has been co-speciated
with Old World primates for about 30 million years, making them the oldest
known vertebrate RNA (ribonucleic
acid) or retroviruses.
late 1950's SV40, a
retrovirus, is identified in the injected form of the
This is believed to be
due to kidney cells from infected monkeys
being used to amplify the vaccine virus
Both the Sabin vaccine (oral, live virus) and
the Salk vaccine (injectable, killed virus) are
affected; the technique
used to inactivate the polio virus in the Salk vaccine, by means of
not reliably dissolve SV40.
When two or more vaccines are mixed together
in the same formulation, the two vaccines can interfere.
frequently occurs with live attenuated vaccines, where one of the vaccine
components is more robust than the others and suppresses the growth and
immune response of the other
This phenomenon is first noted in the trivalent Sabin polio
vaccine, where the amount of serotype 2 virus in the vaccine has to be reduced
to stop it from interfering with the "take" of the serotype 1 and 3 in the
SIVagm is a lentivirus also a retrovirus.
The genome consists of two strands, a longer negative-sense strand and
a shorter and positive-sense strand of variable length.
In the virion
these strands are arranged such that the two ends of the long strand meet but
are not covalently bonded
The virus binds to receptors allowing viral particles to enter
This is then translocated to the nucleus, where the
partially double stranded DNA is 'repaired' by the
viral polymerase to
form a complete circular dsDNA genome (called covalently-closed-circular DNA or
The genome then undergoes transcription
by the host cell RNA polymerase and the pregenomicRNA (pgRNA) is sent out of
A polymerase is an enzyme that
synthesizes long chains of
(DNA polymerase and RNA polymerase are used to assemble
DNA and RNA molecules, respectively, by copying a DNA template strand using
base-pairing interactions or RNA by half ladder replication.)
penetrates an assembled viral capsid containing the viral polymerase.
Inside this capsid the genome is converted from RNA to pdsDNA through
activity of the polymerase as an RNA-dependent-DNA-polymerase and subsequently
as an RNAse to eliminate the pgRNA transcript.
New virions either leave
the cell to infect others or are immediately dismantled so the new viral
genomes can enter the nucleus and magnify the infection.
that leave the cell egress through budding.
This is a deoxyribonucleic
1958 Denis Parsons Burkitt describes
a B lymphocytes cancer of the lymphatic system found in the germinal center.
Michael Anthony Epstein, a British pathologist and academic, proposes
Burkitt's lymphoma is a cancer caused by a virus.
Epstein changes his
research focus to a viral origin of Burkitt's lymphoma.
After more than
two years of working with tumour cells from Burkitt's patients Epstein claims
to have isolated the the EpsteinBarr virus.
also known as human herpesvirus 4, is a member of the herpes virus family. It
is one of the most common human viruses.
EpsteinBarr infection is
found in most patients with Burkitt lymphoma.
Burkitt lymphoma strikes
30-40% of individuals with HIV-induced AIDS.
Mononucleosis is thought to
spread most commonly through bodily fluids.
Adolescents were told if you
kissed you would get the Kissing disease.
Infectious Mononucleosis (Mono) | Epstein-Barr
Exaggerated Villainy of the Epstein-Barr Virus
Neurological Symptoms in Multiple Sclerosis
Morphologic Features of Epstein-Barr Virus Infection in the GI
Relationship between Epstein-Barr and Cell
"Blastoid cell cultures derived from leukocytes of patients
in the acute stage of infectious mononucleosis (IM) and harboring Epstein-Barr
(EB) virus in at least 1% of the cells were found to possess antigens in their
membranes which presently are indistinguishable from those detected in
Burkitt's lymphoma (BL) cells by the techniques employed." - Rockefeller
1960s Researchers "isolate" and
then inoculate with the MS-2 strain of hepatitis B virus.
viruses replicates through an RNA intermediate form by reverse transcription,
and in this respect they are similar to retroviruses.
Hepatitis B virus
belongs to the Hepadnavirus family.
Hepadnaviruses have very small
genomes of partially double-stranded, partially single stranded circular DNA.
Was There an AIDS Contract?
What Really Caused The AIDS Epidemic?
early 1970s African rhesus monkeys are used in the manufacture
of the hepatitis B vaccine.
Human hepatitis B viruses cultured
in vivo in rhesus monkeys are
returned to humans whose infected blood serum is then pooled to develop four
different strains of experimental hepatitis B vaccine.
vaccine clinical trial in New York City and central Africa.
Hepatitis B vaccine recipients worldwide,
including gay men in New York, and
Black Africans in Central
Africa, are exposed to simian viruses including SV40, SIVagm, and perhaps
A generally neglected evolutionary route of
SIVagm to HIV-1 zoonosis sequentially
a) human incubation for more than a decade of polio vaccine
contaminants and recombinants including
SV40, SFR, and possibly SIVagm;
b) the pooling of infected blood serum
donated by hundreds of gay American and Black African
hepatitis B vaccine recipients who had
subsequently received injections with cultured
strains of hepatitis B virus;
c) the biohazardous laboratory
conditions and viral containment problems reported by the
hepatitis B vaccine investigators and
This series of events provides the best explanation
for an early to mid-1970s "punctuated origin event" most precisely fitting
etiological determinations of the
There is evidence demonstrating
that the schizophrenia associated
retrovirus (SZRV) is an autoimmune
disorder causing retrovirus in the Type-D family of retroviruses, e.g.,
SRV-1 (simian retrovirus type 1), SRV-2 (simian retrovirus type 2), M7 (baboon
endogenous retrovirus), SMRV-H (squirrel monkey retrovirus), HTLV (human T lymphocyte leukaemia virus) and
distantly-related to HIV (human
1972 World Health Organization Bulletin No. 47
refers to creation of an immune virus and suggests that a useful way to study
the effects would be "to put it into a vaccination program and observe the
Curiously the spread of
HIV infection in Central Africa
coincides precisely with an intense
smallpox vaccination campaign.
Information on Central African
countries infected with HIV matches WHO figures indicating the number of people
vaccinated in these areas.
Documents Locked Up for 30 Years Prove This Vaccine
|HIV vaccine development
presents novel challenges on multiple levels.
The chief challenge is
HIV human retrovirus replicates by irreversibly inserting its genes into the
HIV infection is established permanently in a matter of
days or even hours, and it cannot be cleared by primary or anamnestic
In addition to integrating into the host genome, HIV
replicates in CD4+ T cells that are key players in protective immunity.
These features suggest a different path to a HIV vaccine from
traditional design that led to successful vaccines against other infectious
Inability to yield an HIV vaccine became abundantly clear in
six large HIV vaccine trials, where efficacy was not observed.
Strikingly, vaccination increased the risk of infection in two of these
studies that selectively targeted T-cell immunity, providing a stark contrast
between the development of conventional and HIV vaccines.
1983 French team at the Pasteur Institute
in Paris led by Luc Montagnier, publish a paper in Science describing a
retrovirus, LAV (lymphadenopathy associated
virus), isolated from a patient at risk for
May 6, 1983 "The disease
was first believed to be confined to a particular epidemiologically defined
segment of the population.
Earlier hypotheses suggested there was
something within the lifestyle of male homosexuals that predisposed them to
Theories put forth suggesting drugs such as amyl nitrite,
antigenic overload, and medications taken for multiple infections affecting
male homosexuals." - Anthony S. Fauci, National Institutes of Health;
Acquired Immune Deficiency Syndrome: Ever-Broadening Clinical
May 4, 1984 Robert
Gallo, a researcher at the National
Cancer Institute where he has worked for 30 years mainly as head of the
Laboratory of Tumor Cell Biology, and collaborators publish a series of
four papers in Science demonstrating that a retrovirus they claim to
have isolated is the cause of AIDS, HTLV-III, related to the
leukaemia viruses of Gallo's
Method of continuous production of retroviruses
1987 Out of court settlement
between the National Institutes of
Health (NIH)and Pasteur Institute in Paris.
our analysis suggest that subjects with bipolar disorder and history of
cannabis use disorders demonstrate significantly better neurocognitive
performance, particularly on measures of attention, processing speed, and
These findings are consistent with a previous study
that demonstrated that bipolar subjects with history of cannabis use had
superior verbal fluency performance as compared to bipolar patients without a
history of cannabis use (Ringen et al., 2010).
Similar results have
also been found in schizophrenia in several
studies (Rabin et al., 2011).
These data could be interpreted to
suggest that cannabis use may have a beneficial effect on cognitive functioning
in patients with severe psychiatric disorders.
Amalgamated HepB vaccine
Amalgamated HepB vaccine
mandated by Centers for Disease Control in 44 US states for initial use
in infants as young as two months.
New York Times, Mar 17th, "US
Vaccine Plan Uses Welfare Offices":
considered denying nutritional benefits to families who refuse vaccinations.
The begins the process of mandating Hepatitis B vaccinations for all
infants in the United States. Many infants receive multiple doses from birth.
Following years of controversy surrounding the out of court settlement
between the National Institutes of Health and the Pasteur
Institute, Gallo admits the virus he claimed to have discovered in 1984 is
in reality a virus sent to him from France the year before, putting an end to a
six-year effort by Gallo and his employer, the National Institutes of
Health, to claim the AIDS virus as an
B vaccination of male neonates and autism diagnosis
Court Admits Hepatitis B Vaccine Caused Fatal Autoimmune
Connective Tissue Disease Following Hepatitis B
1993 "This paper shows how to
equate different aspects of imperfection in a prophylactic vaccine in terms of
impact upon levels of herd immunity, and hence upon the vaccine coverage
required for eradication.
that an otherwise perfect vaccine that gives protection which wanes with a
half-life of 10 years is only as good as a vaccine that works in 30% of people
giving them complete, lifelong protection." - Imperfect vaccines and herd immunity to HIV
1994 20,000 American children and adolescents are
diagnosed with bipolar disorder.
1995 Gallo with
his colleagues Paolo Lusso and Fiorenza Cocchi
publish their discovery
that chemokines, a class of naturally occurring compounds, are potent and
specific HIV inhibitors.
This discovery is heralded by Science
magazine as one of the top scientific breakthroughs of the year.
role chemokines play in controlling the progression of HIV infection influences
thinking on how AIDS works against the
1996 "Despite unanimous
literature of double-blind studies indicating
are no more effective than placebo in treating depression in children and
adolescents, such medications continue to be in wide use." - Rhoda L. Fisher
and Seymour Fisher, "antiDepressant for Children," The Journal of Nervous
and Mental Diseases (1996, v.184, no.2)
Gallo, Robert R. Redfield
and William A. Blattner, found the Institute of Human
800,000 children and adolescents are diagnosed with bipolar
disorder - exponentially increasing 40 times levels 9 years
2005 Dr. Frederick K.
Goodwin warns that children
with bipolar disorder who were left untreated could suffer brain damage.
Dr. Frederick K. Goodwin, a former director of the National Institute of Mental
Health, and host of the popular public radio program "The Infinite
Mind," produced by Lichtenstein Creative Media, earns at least $1.3
million from 2000 to 2007 giving marketing lectures for drugmakers.
"Boys, behaving aggressively
exhibiting irritable behavior become compliant when given mood stabilizers and
parents are relieved of the
stigma of poor parenting as bipolar disorder is thought to be an
Modern treatments - mood stabilizers in
particular - have been proven both
safe and effective
in bipolar children." -
Frederick K. Goodwin
"I call it the
juvenile bipolar juggernaut.
The diagnoses has been broadened considerably and I think that's a big
problem." - Joseph Woolston, Yale
"The risk of violence on these
drugs has been known for 50 years.
Giving these drugs to healthy
volunteers can cause them to become violent.
The data has been out
there in warnings in many countries for years.
There is no doctor who can say
they have been unaware of this issue.
If there are,
they are simply not
professional." - David Healy
2007 Gallo and his team are awarded a $15 million grant from
the Gates Foundation for
research into a preventive vaccine for HIV/AIDS.
"To develop safer and more effective
vectors for gene therapy of X-linked severe combined immunodeficiency
(SCID-X1), we have evaluated new self-inactivating lentiviral vectors based on
the HIV virus.
The CL20i4-hγc-Revgen vector contains the entire
human common γ chain (γc) genomic sequence driven by the
-hγcOPT vector uses a promoter fragment from the eukaryotic
elongation factor alpha (EF1α ) gene to express a codon-optimized human
Both vectors contain a 400-bp insulator
fragment from the chicken ß-globin locus within the self-inactivating
Transduction of bone marrow cells using either of
these vectors restored T, B, and natural killer lymphocyte development and
function in a mouse SCID-X1 transplantation model.
human CD34+ bone marrow cells from SCID-X1 patients with either
vector restored T-cell development in an in vitro assay.
studies using a Jurkat LMO2 activation assay, only the
CL20i4-EF1α-hγcOPT vector lacked the ability to
transactivate LMO2 protein expression, whereas the
CL20i4-hγc-Revgen vector significantly activated LMO2 protein
In addition, the CL20i4-EF1α-hγcOPT
vector has not caused any tumors in transplanted mice.
We conclude that
the CL20i4-EF1a-hγcOPT vector may be suitable for testing in a
clinical trial based on these preclinical demonstrations of efficacy and
A self-inactivating lentiviral vector for SCID-X1 gene
2011 Gallo and his team received
$23.4 million from a consortium of funding sources to support the next phase of
research into the Institute of Human Virology's (IHV) promising HIV/AIDS
preventive vaccine candidate.
The IHV vaccine program grants included
$16.8 million from the Gates
Foundation, $2.2 million from the U.S. Army's Military HIV Research
Program (MHRP), and other research funding from a variety of sources including
the National Institutes of Health.
Gene correction in human long-term hematopoietic
stem cells (LT-HSCs)
could be an effective therapy for monogenic diseases of the blood and immune
Here we describe an approach for X-linked sSevere cCombined
iImmunodeficiency (SCID-X1) using targeted integration of a cDNA into the
endogenous start codon to functionally correct disease-causing mutations
throughout the gene.
Using a CRISPR-Cas9/AAV6 based strategy, we
achieve up to 20% targeted integration frequencies in LT-HSCs.
measures of the lack of toxicity we observe no evidence of abnormal
hematopoiesis following transplantation and no evidence of off-target mutations
using a high-fidelity Cas9 as a ribonucleoprotein complex.
high levels of targeting frequencies (median 45%) in CD34+ HSPCs
from six SCID-X1 patients and demonstrate rescue of lymphopoietic defect in a
patient derived HSPC population in vitro and in vivo.
In sum, our study
provides specificity, toxicity and efficacy data supportive of clinical
development of genome editing to treat SCID-Xl.
correction for SCID-X1 in long-term hematopoietic stem
|Gastrointestinal (GI) tract disease/inflammation is a hallmark of
Recreational and medical use of cannabis among human
immunodeficiency virus (HIV)-infected individuals has increased in recent
In simian immunodeficiency virus (SIV)-infected macaques,
chronic administration of Δ9tetrahydrocannabinol
(Δ9THC) inhibited viral replication and intestinal inflammation
and slowed disease progression.
inflammation has been proposed to facilitate microbial translocation and
systemic immune activation and promote disease progression.
including Δ9THC attenuated intestinal inflammation in mouse
colitis models and SIV-infected rhesus macaques.
To determine if the
anti-inflammatory effects of Δ9THC involved differential mRNA
(mRNA) modulation, we profiled mRNA expression at 14, 30, and 60 days
postinfection (days p.i.) in the intestine of uninfected macaques receiving
Δ9THC (n=3) and SIV-infected macaques administered either
vehicle (VEH/SIV; n=4) or THC (THC/SIV; n=4).
Δ9THC administration to uninfected macaques significantly and
positively modulated intestinal mRNA expression by increasing the total number
of differentially expressed mRNAs from 14 to 60 days p.i. At 60 days p.i., ~28%
of mRNAs showed decreased expression in the VEH/SIV group compared to none
showing decrease in the THC/SIV group.
Furthermore, compared to the
VEH/SIV group, THC selectively upregulated the expression of miR-10a, miR-24,
miR-99b, miR-145, miR-149, and miR-187, previously been shown to target
NOX4, a potent reactive oxygen species
generator, was confirmed as a direct miR-99b target. A significant increase in
NOX4+ crypt epithelial cells was detected in VEH/SIV macaques compared to the
We speculate that miR-99b-mediated NOX4 downregulation
may protect the intestinal epithelium from oxidative stress-induced damage.
These results support a role for differential mRNA induction in
THC-mediated suppression of intestinal inflammation.
mRNA modulation occurs in other tissues requires further
Previously, we showed that chronic treatment of
SIV-infected macaques with Δ9tetrahydrocannabinol
(Δ9THC) increased survival and decreased viral replication and
infection-induced gastrointestinal inflammation.
Here, we show that
chronic THC administration to SIV-infected macaques induced an
anti-inflammatory mRNA expression
profile in the intestine at 60 days p.i.
These included several mRNAs
bioinformatically predicted to directly target CXCL12, a chemokine known to
regulate lymphocyte and macrophage trafficking into the intestine.
Specifically, mR-99b was significantly upregulated in THC-treated
SIV-infected macaques and confirmed to directly target NADPH oxidase 4 (NOX4),
a reactive oxygen species generator known to damage intestinal epithelial
Elevated mR-99b expression was associated with a significantly
decreased number of NOX4+ epithelial cells in the intestines of THC-treated
Overall, our results show that selective
upregulation of anti-inflammatory
mRNA expression contributes to THC-mediated suppression of gastrointestinal
inflammation and maintenance of intestinal homeostasis.
This web site is not a commercial web site and
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This website defines a
new philosophical ideology to which its author adheres. The author feels that
the falsification of reality outside personal experience has forged a populace
unable to discern propaganda from reality and that this has been done
purposefully by an international corporate cartel through their agents who wish
to foist a corrupt version of reality on the human race. Religious intolerance
occurs when any group refuses to tolerate religious practices, religious
beliefs or persons due to their religious ideology. This web site marks the
founding of a mystery school aptly named The Truth of the Way of the
Lumière Infinie - a rational gnostic mystery religion based on reason
which requires no leap of faith, accepts no tithes, has no supreme leader, no
church buildings and in which each and every individual is encouraged to
develop a personal relation with the Creator and Sustainer through the pursuit
of the knowledge of reality in the hope of curing the spiritual corruption that
has enveloped the human spirit. The tenets of The Truth of the Way of the
Lumière Infinie are spelled out in detail on this web site by the
author. Violent acts against individuals due to their religious beliefs in
America is considered a "hate crime."
This web site in no way condones
violence. To the contrary the intent here is to reduce the violence that is
already occurring due to the international corporate cartels desire to control
the human race. The international corporate cartel already controls the world
banking system, corporate media worldwide, the global industrial military
entertainment complex and is responsible for the collapse of morals, the
elevation of self-centered behavior and the destruction of global ecosystems.
Civilization is based on coöperation. Coöperation does not occur at
the point of a gun.
American social mores and values have declined
precipitously over the last century as the corrupt international cartel has
garnered more and more power. This power rests in the ability to deceive the
populace in general through corporate media by pressing emotional buttons which
have been preprogrammed into the population through prior corporate media
psychological operations. The results have been the destruction of the family
and the destruction of social structures that do not adhere to the corrupt
international elites vision of a perfect world. Through distraction and
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directed toward solutions proposed by the corrupt international elite that
further consolidates their power and which further their purposes.
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