prescriptions are estimated at 45 million per year.
|Current antibiotic drugs
have limited efficacy against multidrug resistance bacteria
and their usage can be limited due to their toxicity for prolonged treatments;
therefore, the discovery of an antimicrobial therapy of plant origin will no
doubt be a great advancement in the field of anti-infectives.
cannabinoids have been found to have potent antimicrobial activity against
such as MRSA isolates.
Endocannabinoids have also been shown to be
effective in eradicating biofilms.
Combination therapy with
bactericidal agents that possess different modes of action such as polymyxin B
have shown synergism and broad-spectrum activity.
There is evidence
other compounds found in C. sativa such as
terpenes have promising
antimicrobial activity, warranting further investigation.
As bacteria are rapidly
developing resistance against existing drugs, cannabinoids present a
potential new source of antibiotics.
Δ9-THCA, Δ9-THC, CBN, CBD, and CBDA with
binding active site of SARS-CoV-2 Mpro had good docking scores
compared to reference compound a-ketoamide with similar binding pocket of
Δ9-THC and CBD showed a
slightly higher HOMO-LUMO energy gap in DFT calculations; these molecules are
stable with SARS-CoV-2 Mpro.
In MD simulations,
Δ9-THC- or CBD-SARS-CoV-2 Mpro complexes showed
better conformation stability than Δ9-THCA, CBN, and CBDA
Δ9-THC or CBD bind to SARS-CoV-2
Mpro with stable conformations.
Based on privileged safety
index CBD and Δ9THC in human and their current in vitro
potencies against SARS-CoV-2, it can be concluded that these compounds are
potential antiviral molecules towards SARS-CoV-2 and may have worked as
dual-acting against SARS-CoV-2, not only block the viral translation procedure
by inhibiting SARS-CoV-2 Mpro but also
cytokines levels in lung cells by acting as agonists of CB2
doctors set up the US Pharmacopeia and record the first list of standard
1911 US v. Johnson, the Supreme
Court rules that the 1906 Food and Drugs Act does not outlaw false medical
claims but only false and misleading statements about the ingredients or
identity of a drug.
1912 Congress passes the
Sherley Amendment to overcome the ruling in US v. Johnson.
The Act outlaws labeling medicines with fake medical claims that is
meant to trick the buyer.
1937 Elixir Sulfanilamide, contains the poisonous
liquid, diethylene glycol, killing
107 persons, many of whom are children.
Congress passes the Federal Food, Drug, and Cosmetic Act (FDC), which
requires that new drugs show safety before selling.
1941 Nearly 300 deaths and injuries result from the use of
sulfathiazole tablets, an antibiotic, tainted with the
1950 Alberty Food Products
Co. v. US, a US Court of Appeals rules that the directions for use on a
drug label must include reason for
1951 Congress passes the
Durham-Humphrey Amendment, which defines the kinds of drugs that cannot
be used safely without medical supervision.
The amendment limits sale
of these drugs to prescription only by a medical professional.
other drugs are to be available without a prescription.
1952 Nationwide investigation by FDA reveals that
chloramphenicol, an antibiotic, caused nearly 180 cases of often deadly blood
1953 Factory Inspection
Amendment clarifies previous law and requires FDA to give
manufacturers written reports of
conditions seen during inspections and results of factory
are commonly used to treat a variety of infections, including urinary tract,
respiratory tract, gastrointestinal tract, skin, bone, and joint infections.
First introduced in the 1980s to treat gram-negative bacterial
infections, the popularity of fluoroquinolone antibiotics has increased because
of their broad antimicrobial spectrum, multiple approved indications, and
In fact, between 1995 and 2002,
fluoroquinolone prescribing tripled, making fluoroquinolones the class of
antibiotics most commonly prescribed to adults in the United States.
Despite their popularity, a number of
have been attributed to fluoroquinolones, including
on musculoskeletal tissues.
which was first reported in the literature in 1983, is a widely recognized
complication of fluoroquinolone use that eventually led the U.S. Food and Drug
Administration to add a black box warning label to all fluoroquinolones in
2008, citing increased risk of tendinitis and tendon rupture.
a toxic effect not only on tendons but also on cartilage, bone, and muscle.
Knowledge of the full spectrum of the negative effects of
fluoroquinolone antibiotics on the musculoskeletal system is currently
evolving, and much of the mechanistic nature of the
toxicity has not
yet been fully elucidated." - Musculoskeletal Complications of
Fluoroquinolones: Guidelines and Precautions for Usage in the Athletic
Population, Mederic M. Hall, MD, Jonathan T. Finnoff, DO, Jay Smith, MD,
Department of Physical Medicine and Rehabilitation, Mayo Clinic College of
Medicine, Mayo Clinic Sports Medicine Center, Rochester, MN
all chemicals have side effects
most side effects are transient - they cease
when the medication is discontinued - this is NOT the case with Cipro or its
generic cousin Gentamicin !
Cipro, a 100% synthetic chemotherapeutic
chemical, works by interfering with bacterial DNA, preventing it from
How can a synthetic chemical differentiate between
bacterial DNA and your DNA!?
Cipro is a fluoroquinolone (also called
"quinolone" or just "quin") class of chemicals.
Over HALF of all
fluoroquinolone antibiotics have been pulled from the market for their
records - and those remaining (Cipro, Levaquin, Avelox and a few others)
are no safer!
Every single chemical in this class carries a "black box
warning" - the equivalent of a
Cipro's "black box warning" label makes it sound as if
tendon rupture is the worst possible scenario.
Cipro is actually capable
of unleashing an entire SYNDROME of systemic toxicity - "fluoroquinolone
different adverse symptoms are suffered simultaneously and often last a
Cipro-induced toxicity syndrome wreaks absolute havoc on
every part of a person's body - every tendon and joint in the body can become
affected, every organ (including the brain),
system, dystonia, muscle weakness, autonomic
dysfunction, vision damage including temporary blindness, retinal tears and/or
permanent double vision, permanent tinnitus,
long lasting or permanent
central nervous system damage (including relentless insomnia,
memory loss, panic
multiple chemical sensitivities, severe muscle wasting, hair loss, skin
syndrome, extensive dental damage
Cipro is toxic to ALL
connective tissues and the damage is cumulative.
Degeneration of the
cartilage matrix in humans has been observed following as few as two oral doses
People have also suffered
osteonecrosis (bone death) as a result of
Cipro is not even permitted for use in patients under the
age of 18 because it can interfere with the development of a child's
still-growing connective tissues. Cipro can render a top athlete of any age
completely crippled and unable to walk, let alone workout or compete ever
Cipro is capable of causing severe delayed reactions that don't
manifest until long after you've finished taking the chemical.
means is that you could be experiencing a potentially permanent, crippling
reaction to the chemical but have NO IDEA until it's too late! Your risk of
spontaneously tearing or rupturing a tendon continues for up to FIVE YEARS
after you have ingested the medication!
Cipro is also a
neurotoxin capable of
crossing the blood-brain
barrier and causing severe
long-term neuropsychiatric side effects.
relentless insomnia, seizures,
paranoia and hallucinations.
side effects can result from as little as ONE pill and persist for years or in
some instances even be permanent!
Cipro can calcify all of the
nerves in your teeth as well as permanently dry out your mouth, promoting
extensive tooth decay and/or tooth loss.
The vast majority of
physicians are completely ignorant about Cipro and its horrific and
long-lasting side effects.
Most won't believe you when you tell them a
prescription antibiotic has caused your
slew of sudden disabling
health problems - even if your symptoms match the ones listed right on the
chemical's warning label!
Doctors often misdiagnose fluoroquinolone toxicity syndrome victims as
disorders such as multiple
sclerosis, since many Cipro-induced ADR's mimic those of
Other favorite misdiagnosis include reflex sympathetic dystrophy (also
called chronic regional pain syndrome or CRPS),
syndrome, scleroderma, Raynauld's syndrome, and Sjogren's.
There are natural plant based
my cat, thought I was feeding him and jumped into the still wet insecticide so
I grabbed him and he landed a claw in my middle finger knuckle joint
(metacarpals/hamate) which became infected.
(Rhett passed away from
lung cancer - and I know he didn't
I ended up hospitalized.
First they give me a DPT shot
and then three Gentamicin intravenous drips with follow up oral doses of
Gentamicin is an
aminoglycoside antibiotic composed of a mixture of related gentamicin
components and fractions and is used to treat many types of bacterial
It is synthesized by Micromonospora, a genus of
Gram-positive bacteria widely present in the environment (water and soil).
The drug binds avidly to certain tissues. Gentamicin can also be highly
nephrotoxic, particularly if multiple doses accumulate over a course of
For this reason gentamicin is usually dosed by ideal body
Various formulae exist for calculating gentamicin dosage.
Also trough and peak serum levels of gentamicin are monitored during
treatment, generally before and after the third dose is infused.
Gentamicin, like other aminoglycosides, causes nephrotoxicity by
synthesis in renal cells.
This mechanism specifically causes
necrosis of cells in the proximal tubule, resulting in acute tubular necrosis
which can lead to acute renal failure.
Side effects of gentamicin
toxicity vary from patient to patient.
Side effects may become apparent
shortly after or up to months after gentamicin is administered.
Symptoms of gentamicin toxicity that I experienced included: balancing
difficulty, ringing in the ears (tinnitus);
particularly when standing (anger breakdown at 149 over removal or leaving
Psychiatric symptoms related to gentamicin that I experienced
included: confusion and disorientation.
Other side effects I
experienced included: loss of appetite, a severe intestinal condition
(Clostridium difficile-associated diarrhea enhanced with glyphosate) which may
occur during treatment or weeks to months after treatment has stopped.
Many medical practitioners freely administer gentamicin as an
antibiotic without advising patients of the severe and permanent potential
ramifications of its use.
Gentamicin is well known to be a cheap,
low-cost yet old medicine when compared with modern alternatives, and is
typically US$3-6 per dosage less than modern alternatives.
recover from gentamicin toxicity naturally over time if the drug is
discontinued, but they recover slowly and usually incompletely.
Sometimes the toxicity of gentamicin can still increase over months
after the last dose.
Upon cessation of gentamicin therapy symptoms such
as tinnitus and imbalance may become less pronounced.
Do not use
anti-diarrhea products or narcotic pain medications if you have any of the
following symptoms because these products may make them worse:
abdominal or stomach pain/cramping, blood/mucus in your stool.
not a complete list of possible side effects.
2004 Study published in New
England Journal of Medicine systematically documents a dramatic
increase of cardiac arrest associated with
"This study shows the need for continuing research on
the safety of older medicines, including how they interact with newer
chemicals." - observer Wayne A. Ray, a professor of preventive medicine at
School of Medicine in Nashville.
"Nobody realized the magnitude of the
problem before." - Dr. Muhamed Sanc,
director of the electro cardiology laboratory at the University of Medicine
and Dentistry of New Jersey in Newark.
30 million pounds of antibiotics are used in America each year.
though 25 million pounds are used in
animal husbandry to
promote growth, only 2 million pounds of those antibiotics are used for
84% of salmonella is resistant to at least
one antisalmonella antibiotic.
54% of Campylobacter jejuni are
resistant to at least one anti-Campylobacter antimicrobial
2013 US study
shows 35% of anaphylaxis
cases are caused by medications.
In the US
drugs were the most common cause of
anaphylaxis accounting for 60% of all anaphylaxis-related deaths.
the UK drugs are responsible for 42% of all
identified causes of
In Latin America drugs are responsible for 31% of
Ketek (telithromycin)Telithromycin is a semi-synthetic erythromycin derivative.
It is forged by substituting a ketogroup for the cladinose sugar and
adding a carbamate ring in the lactone ring.
FDA approved Ketek,
Sanofi-Aventis, in 2004 to
treat severe infections.
FDA submitted clinical
trial data that key officials knew to be tainted by
including fictitious patients.
Several users of Ketek experience liver
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