Darkness in El Dorado

Darkness in El Dorado (Book Review)

Mother's Little Helper

Prenatal SSRI Exposure and Autism

FDA approves chemical for the annoyingly Cheerful

Blunting emotion can save you money

"If you look at the chemical war from a purely economic point of view, the role of the government is to protect the chemical cartel." - Milton Friedman

"If you aren't happy in your work, that must imply a fault in your production process (socialization, education, training); fortunately, that can be adjusted with pharmaceutical technology." - Charles Eisenstein

antiDepressant increase the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders.

Anyone considering the use of [insert name of pharmaceutical profit center blockbuster] or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need.

"A review of seventy-four clinical trials of antiDepressant found that thirty-seven of thirty-eight positive studies [that praised the chemicals] were published. But of the thirty-six negative studies, thirty-three were either not published or published in a form that conveyed a positive outcome." - Marcia Angell, MD, Executive Editor New England Journal of Medicine


FDA revises labeling requirements for antiDepressant:

antiDepressant are building up in fish brains

Are too many seniors taking antiDepressant?

Single dose of antiDepressant changes the brain

Side Effects: Death - Confessions of a Pharma-Insider

Unlikely 'antiDepressant' Have an Effect on Depression

Drug company-funded anti-suicide groups on campus

"SELECTIVE SEROTONIN REUPTAKE INHIBITOR induced apathy is generally marked by a lack of motivation that is not a result of sedation, change in level of consciousness, or symptoms of a mood disorder (Barnhart et al. 2004; Hoehn-Saric et al. 1990; Marin 1991).

The term apathy is usually defined as a lack of self-initiated responsiveness to stimuli or lack of motivation (Marin 1991; van Reekum et al. 2005).

Apathy, amotivational syndrome, has mainly been reported in adults taking SSRIs (Barnhart et al., 2004; Hoehn-Saric et al., 1990), although a few adolescents - and even fewer children - have been described (Garland and Baerg 2001).

Several names have been used to describe this phenomenon, including SSRI-induced apathy, amotivation, emotional blunting, and drug-induced indifference (Balon 2002; Garland and Baerg 2001; Hoehn-Saric et al. 1990; Riddle et al. 1991).

This SSRI adverse reaction (AE) is easily missed or ascribed to underlying psychopathology and misinterpreted as medication failure, particularly in depressed patients (Garland and Baerg 2001).

This clinical error can sometimes prompt medication dose increases, with consequent exacerbation of the apathy." - Selective Serotonin Reuptake Inhibitor Induced Apathy: A Pediatric Case Series Shauna P. Reinblatt, M.D., FRCPC, and Mark A. Riddle, Journal of Child and Adolescent Psychopharmacology Volume 16, Number 1/2, 2006 Mary Ann Liebert, Inc. Pp. 227–233

The Depressing Side of Medical Science

45% of antidepressants aren't taken for depression

Antidepressants Affect People's Moral Behavior


serotonin = 5-hydroxytryptamine

tryptophan = 5-hydroxytryptophan

dopamine = 3,4-dihydroxyphenethylamine

melatonin = N-acetyl-5-methoxy tryptamine

norepinephrine = noradrenaline = 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)

epinephrine = adrenaline = 1,2-Benzenediol, 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]

"All the selective serotonin reuptake inhibitors [including Prozac® and Luvox®] relieve the patient of feeling.

He becomes less empathic, as in I don't care as much,' which means
'It's easier for me to harm you.'

If a doctor treats someone who needs a great deal of strength just to think straight, and gives him one of these chemicals, that could push him over the edge into violent behavior." - Dr. Joseph Tarantolo, American Society of Psychoanalytic Physicians

5 of the top 10 violence-inducing chemicals are antiDepressant:

fluoxetine (Prozac®)
paroxetine (Paxil®)
fluvoxamine (Luvox®)
venlafaxine (Effexor®)
desvenlafaxine (Pristiq®)

400% Increase in Antidepressant Use

Antidepressant prescribing has risen nearly 400% since 1988,
according to data from the Centers for Disease Control

Percentage of Americans on antiDepressant Doubles

From 1999 to 2012 the percentage of Americans on antiDepressant increased from 6.8% to 13%,
according to a report published this week by the Journal of the American Medical Association (JAMA).

Selective serotonin reuptake inhibitors ( SSRI) increase the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor.

It is generally thought that tricyclic antiDepressant work by inhibiting the re-uptake of the neurotransmitters norepinephrine and serotonin.

"Since it has been suggested that the OFC is critically involved in both reversal learning and delayed pattern recognition (Rogers et al. 1999a; Rubinsztein et al. 2001) and that this is assumed to be a key site of dysfunction in fvFTD (Rahman et al. 1999), it is important to attempt to understand the changes effected by paroxetine in this area.

Blier and de Montigny (1998) found that the evoked release of tritiated 5-HT in the guinea pig was significantly enhanced in the OFC after an 8-week course of high-dose paroxetine or fluoxetine but not after 3 weeks.

Although a 4-to-6-week study period is conventional for testing the efficacy of a treatment for depression, 8–12 weeks is typically used in assessment of SSRI treatment of obsessive–compulsive disorder (Montgomery 1996).

It is possible that a longer course of paroxetine could produce different results on neuropsychological measures and perhaps even subjective measures." - Paroxetine does not improve symptoms and impairs cognition in frontotemporal dementia: a double-blind randomized controlled trial, Psychopharmacology (2004) 172:400–408 DOI 10.1007/s00213-003-1686-5, J. B. Deakin, S. Rahman, P. J. Nestor, J. R. Hodges, B. J. Sahakian

Antidepressant Nightmares

Antidepressants Banned for UK Kids

SSRI use in pregnancy linked to boys' autism risk

Crime risk rises for young people on antidepressants

Kids' Suicide Risk Similar for All Newer Antidepressants

Antidepressants Double the Risk of Aggression and Suicide in Children

1987 to 1996

Psychotropic chemical use among children and teens nearly triples.

1997 Joseph Westbecker, prescribed Prozac®, kills himself and eight others at a Louisville, Kentucky printing plant after being fired.

Eli Lilly settles charges and the judge seals the case.

1998 Andrew Golden, age 11, Ritalin® and Mitchell Johnson, aged 14, Ritalin® shot 15 people, killing four students, one teacher, and wounding 10 others.

Kip Kinkel, age 15, (on Prozac® and Ritalin®) shoots his parents while they sleep then goes to school and opens fire killing 2 classmates and injuring 22 shortly after beginning Prozac® treatment.

1999 Eric Harris age 17 (first on Zoloft® then Luvox®) and Dylan Klebold age 18, kill 12 students and 1 teacher, and wound 23 others, before killing themselves.

Klebold's medical records have never been made available to the public.

TJ Solomon, age 15, Ritalin® high school student in Conyers, Georgia opens fire on and wounded six of his class mates.

"In summary, emotional blunting associated with SSRI treatment may be more common than previously thought.

Further study is required to determine the frequency of this phenomenon, whether it is associated primarily with SSRI antidepressants, whether usually associated with the presence of sexual dysfunction, and what the functional implications of these symptoms are.

We speculate that in some patients, rather than representing a side-effect, blunting of emotional response may be the central therapeutic effect of SSRIs." - Emotional blunting associated with SSRI-induced sexual dysfunction. Do SSRIs inhibit emotional responses?

zoloft zombie

Antidepressants Cause Violence

The Violent Side Effects of Antidepressants that Many Ignore

Stopping SSRI Antidepressants Can Cause Long, Intense Withdrawal Problems

2001 Christopher Pittman, age 12, murders both his grandparents while taking Zoloft®

Kara Jaye Anne Fuller-Otter, age 12, is on Paxil® when she hangs herself from a hook in her closet.

"The damn doctor wouldn't take her off it and I asked him to when we went in on the second visit. I told him I thought she was having some sort of reaction to Paxil®." - Kara's mother

Cory Baadsgaard, age 16, Wahluke High School, had recently switched to the new antidepressant Effexor, amping up his dosage from 40 milligrams to 300 which caused him to have hallucinations when he took a rifle to his high school and held 23 classmates hostage.

He has no memory of the event.

2002 157 million antiDepressant prescriptions are dispensed in America:

Sertraline, Zoloft®, Lustral®, Serlain®, Paroxetine, Paxil®, Seroxat®, Sereupin®, Aropax®, Deroxat®, Rexetin®, Xetanor®, Paroxat®, Fluoxetine, Prozac®, Fontex®, Seromex®, Seronil®, Sarafem®, Fluctin®, Fluox®, Depress®, Lovan®, Citalopram, Celexa®, Cipramil®, Dalsan®, Recital®, Emocal®, Sepram®, Seropram®, Citox®.

"The pharmaceutical industry often touts its commitment to research to benefit patients.

Internal pharmaceutical industry documents suggest a different motivation for research.

An internal document from Pfizer states that research is done to "Optimize our ability to sell Zoloft [sertraline] more effectively... the purpose of data is to support, directly or indirectly, marketing of our product."

An Eli Lilly document states that the company should: "Develop scientific research and publications plan that enhances credibility of the new positioning and enables the achievement of the ideal positioning ... Mine existing data to generate and publish findings that support the reasons to believe the brand promise." - Glen Spielmans

In The Illusion of Evidence-Based Medicine: Exposing the crisis of credibility in clinical research Jon Jureidini and Leemon B McHenry describe problems with two industry-funded antidepressant randomised controlled trials.

Study 329 examined paroxetine and was funded by SmithKlineBeecham (now GSK); and CIT-MD-18 was a citalopram trial funded by Forest Laboratories.

Internal communications show sponsors knew efficacy results were negative, yet journal articles and marketing efforts claim treatment efficacy.

Adverse events were also mischaracterised and underreported.

Marketing clearly trumped science, which is stated bluntly in several internal communications described by Jureidini and McHenry.

Those who control evidence control evidence based medicine

2003 Over 30 million Americans take antidepressant chemicals, Prozac®, Zoloft®, Paxil®, Luvox®, Celexa®, Lexapro®, Effexor®, Wellbutrin®, Serzone® and Remeron®.

The first seven are 'serotonin reuptake inhibitors,' and their sales exceeded those of any other chemical class except opiates.

2004 FDA warns physicians, patients and their families that popular antiDepressant can cause deepening depression and even suicide.

AntiDepressant use has been associated with agitation, hostility, mania and other forms of violent and/or antiSocial behavior.

Violence and Suicide Caused by antiDepressant Report to the FDA

Rick Lohstroh's 10 year old son, on Prozac®, shoots his father dead.

The boy is given a 10 year prison sentence.

Alex Kim, age 13, hangs himself when his Lexapro® prescription is been.

"Reporting of medical errors affecting children is a significant problem, particularly among physicians." - Agency for Healthcare Research (AHRQ)

2005 Jeff Weise, age 16, prescribed 60 mg/day of Prozac (three times the average starting dose for adults!) shoots his grandfather, his grandfather's girlfriend and many fellow students at Red Lake, Minnesota.

He then shot himself. 10 dead, 12 wounded.

2007 Asa Coon, Cleveland, age 14, wounds four before killing himself.

Court records show Coon was on Trazodone®.

2010 Hammad Memon, age 15, shoots and kills a fellow student.

Hammad has been diagnosed with ADHD and depression, prescribed Zoloft® and "other chemicals for the mental disorders."

and then:

Antidepressant-like effects of cannabidiol

Antidepressant-like effects of Δ9-tetrahydrocannabinol

Antidepressant-like effect of Δ9-tetrahydrocannabinol

Childhood Adversities Increase Risk of Psychosis

Gabriel Myers, 7 years old, hangs himself while in foster care.

Gabriel was prescribed Vyvanse®, an attention deficit/hyperactivity disorder chemical for children aged 6 through 12, Lexapro®, an anti-depressant, and Zyprexa®, an antiPsychotic chemical - both not approved for children.

Symbyax®, an atypical antiPsychotic approved by the FDA for the treatment of schizophrenia, is prescribed to replace Lexapro® and Zyprexa® shortly before Gabriel Myers death.

Gabriel's mother is in prison for chemical abuse.

''We are devastated. Gabriel's problems could not be solved by a pharmacy.'' - Jon Myers, Gabriel's uncle

Chris Fetters, age 13, kills his favorite aunt while taking Prozac®.

Elizabeth Bush, age 13, Paxil® is responsible for a school shooting in Pennsylvania.

Mathew Miller, age 13, hangs himself in his bedroom closet after taking Zoloft® for 6 days.

Rod Mathews, age 14, Ritalin® beats a classmate to death with a bat.

Michael Carneal, age 14, Ritalin® opens fire on students at a high school prayer meeting.

Jarred Viktor, age 15, after five days on Paxil® stabs his grandma 61 times.

Chris Shanahan, age 15, Paxil® in Rigby, ID kills an unfamiliar woman.

Luke Woodham, age 16, Prozac® kills his mother and then kills two students, wounding six others.

Jon Romano, age 16, on medication for depression, fires a shotgun at a teacher in his New York high school.

Julie Woodward, age 17, is on Zoloft® when she hangs herself in her family's detached garage.

Kurt Danysh, age 18, on Prozac®, kills his father with a shotgun.

Kurt is now behind prison bars.

Kurt now writes letters, trying to warn the world that SSRI can kill.

"Emergence of self-destructive phenomena in children and adolescents during fluoxetine treatment," published in the Journal of the American Academy of Child and Adolescent Psychiatry (1991, vol.30), written by RA King, RA Riddle, et al, reports self-destructive phenomena in 14% (6/42) of children and adolescents (10-17 years old) who had treatment with fluoxetine for obsessive-compulsive disorder.

"In the last few years the psychiatric field has been characterized by very expensive chemicals, which, at best, are not inferior to previous chemicals.

To give an example: escitalopram (from citalopram), paliperidon (from risperidon), mirtazapine (from mianserine), pregabalin (from gabapentin), etc.

Many new antiPsychotics aren't better than older ones for effectiveness or side effects." - Vincenzo Fricchione Parise 02/06/09

Top Ten Legal Drugs Linked to Violence

2008 Journal of the American Medical Association finds reporters fail 42% of the time to mention PHRMA funding of research cited in "news" stories.

67% of "news" stories mention brands of chemicals rather than generic chemical names, reinforcing PHRMA marketing campaigns.

In Toxic Psychiatry, Dr. Peter Breggin discusses the subject of chemical combinations:

"Combining antiDepressant [e.g., Prozac®, Luvox®] and psychostimulants [Ritalin®] increases the risk of serious cardiovascular seizures and psychosis.

Withdrawal from the combination can cause a severe reaction that includes confusion, emotional instability, agitation, and aggression."

"I approached ACLU about the fact that there are people in prison who are likely there because their chemicals caused them to become violent but didn't even get an acknowledgment from ACLU that I had written." - Dr. David Healy, professor of psychiatry and Secretary of British Association for Psychopharmacology, author of Let Then Eat Prozac and Mania


ICU Delirium Leads To Symptoms Of Dementia After Discharge

"Observers are alarmed by what they are finding as they track patients for months or years after an ICU stay.

Patients, even young ones, can be weak for years.

Some have difficulty thinking and concentrating or have post-traumatic stress disorder and terrible memories of nightmares they had while heavily sedated.

Observers are increasingly convinced that spending days, weeks or months on life support in the units can elicit unexpected, long-lasting effects." - Gina Kolata, January 11, 2009

Dr. O. Joseph Bienvenu worries about post-traumatic stress disorder.

Many remember nothing, others cannot forget horrifying hallucinations.

Mechanical ventilator tubes and machine hookups are terrifying.

Their illnesses produce delirium, but so do the drugs used in sedation.

Ventilator associated pneumonia and infection control

Volatile organic compounds in ventilated critical care patients

Potential risk for bacterial contamination in conventional reused
ventilator systems and disposable closed ventilator-suction systems

Chinese guidelines for the diagnosis and treatment of hospital
acquired pneumonia and ventilator associated pneumonia in adults

Volatile organic compounds: ventilator-associated pneumonia

"One man told me he saw children's faces that were blacked out and blood running down the walls," Dr. Bienvenu said. "He thought he'd been kidnapped and tortured. One woman said she saw her husband and a nurse talking, and she thought they were plotting to kill her."

Scientists are beginning to worry about the effects of simply being in an intensive care unit, on a mechanical ventilator that pushes oxygen under pressure in and out of the lungs, receiving doses of sedatives, narcotics and anesthetics high enough to make even healthy people stop breathing on their own (patients who are resting and sedated are also given less oxygen).

They have been particularly surprised by how quickly patients lost strength.

It looks like what was lost may not completely come back, even years later.

Dr. John Kress, director ICU University of Chicago, wondered whether the sedatives keeping patients comfortable might be making them worse.

They woke patients briefly every day by turning off the infusion of sedatives.

Patients actually had significantly lower rate of post-traumatic stress disorder, which is manifested by such things as mood disorders, anxiety, difficulty concentrating, shortness of temper and frightening memories.

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