|The hype about
'herd immunity' unfortunately creates a wall of hostility between those who
vaccinate and those who delay some vaccines, avoid certain vaccines, or quit
Since the beginning of vaccination, there is
little proof that vaccines are responsible for eradicating disease even when
'herd immunity' vaccination levels have been reached.
doctors rattle on about your unvaccinated neighbor being the biggest threat to
your child as if vaccination was the only way to avoid an illness or stay
To make matters worse, this intimidation to vaccinate is
played out in an environment where
WHO and vaccine manufacturers
have been accused of scandalous misrepresentations of
disease risk, vaccine safety and effectiveness.
|Virion are also
known as "viral particles," and they are the means by which viral nucleic acids
are able to move and 'infect' living organisms.
Without the viral
particle (taxi) to carry around the virus DNA (passenger), it would be
harmless; in fact, viruses are often described as existing somewhere between
living and inanimate objects for this reason: they do not produce their own
energy, nor are transmissable without a living host.
Viral nucleic acids, simply pathogenic strings of DNA
or RNA, are not even alive, and can not infect an organism without all the
other components (proteins,
lipids, extra-viral nucleic acids)
which are, technically, not viral in origin, participating in the process.
virion architecture includes substantial quantities of host proteins as
well as the viral protein."
share stunning similarities to naturally occurring virus-like particles
produced by all living cells called exosomes.
Exosomes, like many
viruses (i.e. enveloped viruses) are enclosed in a membrane, and are within the
50-100 nanometer size range of virus.
They contain biologically active
molecules, such as proteins and lipids, as well as information-containing ones
like RNAs, very similar, to the types of contents you find in viral
(CoVs), enveloped positive-sense RNA viruses, are characterized by club-like
spikes that project from their surface, an unusually large RNA genome, and a
unique replication strategy.
Coronaviruses cause a variety of diseases
in mammals and birds ranging from enteritis in cows and pigs and upper
respiratory disease in chickens to potentially lethal human respiratory
Here we provide a brief introduction to coronaviruses
discussing their replication and pathogenicity, and current prevention and
We also discuss the outbreaks of the highly
pathogenic Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the
recently identified Middle Eastern Respiratory Syndrome Coronavirus
positive RNA-enveloped viruses.
The first two human coronaviruses,
HCoV-229E and HCoV-OC43, were discovered in the mid-1960s.
They are a
well-known cause of the common cold.
The world epidemic of severe acute
respiratory syndrome human coronavirus (SARS-HCoV) in 20022003 reintroduced the
In 2004 and 2005, respectively, two new
coronaviruses were discovered: NL63 and HKU1.
The Coronaviridae family
is further subclassified into two genera: the alpha coronaviruses (HCoV-229E
and HCoV-NL63) and beta coronaviruses (HCoV-HKU1, HCoV-OC43, Middle East
respiratory syndrome [MERS]-HCoV, and SARS-HCoV).
causes mostly upper and at times lower respiratory tract infection,
pneumonia, and also croup
In 2012, another coronavirus-related epidemic occurred,
this time in the Middle East,
which led to the identification of the MERS-HCoV.
|The discovery of
the HCoV-NL63 and other novel human coronaviruses does not necessarily
represent a sudden increase in emerging infections by 'new' coronaviruses.
In the early 1960s, viral agents causing upper respiratory tract
infections were isolated from patients and were subsequently shown to be
coronaviruses by electron microscopy.
At least four of these were shown
to be serologically distinct from the known coronaviruses at the timeHCoV-NL63
has been shown to infect mainly children and the immunocommpromised, who
presented with either mild upper respiratory symptoms (cough, fever and
rhinorrhoea) or more serious lower respiratory tract involvement such as
bronchiolitis and croup, which was observed mainly in younger children.
HCoV-NL63 is the aetiological agent for up to 10% of all respiratory
Mode of Entry into the Cell: It is well documented that
SARS-CoV and HCoV-NL63 use the same receptor, angiotensin converting enzyme
(ACE)-2, for entry into the host cell.
SARS-CoV causes severe
respiratory distress, while HCoV-NL63 might lead to a mild respiratory
This was attributed to the ability of each virus
receptor-binding protein, spike or S protein, to bind to ACE-2 on the cell
It was found that the HCoV-NL63 S protein has a weaker
interaction with ACE-2 than the SARS-CoV S protein.
interaction with ACE-2 might partly explain the different pathological
consequences of infection by SARS-CoV and HCoV-NL63.
is expected to evolve with coronaviruses.
As for HCoV-NL63, the
possibility of the development of a recombinant virus variant is high because
of its high prevalence and the possibility of a recombination event through
Moreover, the virus is able to survive for up to seven
days in an aqueous solution and respiratory secretions and remains infective at
In heavily populated regions, direct person-to-person
transmission is considered the major route of HCoV-NL63
Donaldson and colleagues have reported the assembly of a
full-length infectious HCoV-NL63 clone, which will make the study of this virus
easier, improving our understanding of the role of each of the proteins encoded
by the HCoV-NL63 genome.
|Of the 674 Health
Care Workers, 353 (52%) reported mild, self-limiting illnesses during the
period between the times when the first and second blood samples were
None of the 674 Health Care Workers was shown to have IgG
antibody to SARS CoV.
|An outbreak of
severe acute respiratory syndrome (SARS) in humans, associated with a new
coronavirus (SARS-CoV), has been reported in
Asia, Europe, and North America.
We have experimentally inoculated
chickens and swine.
Both species are natural hosts for a number of
viruses from the same family as SARS-CoV (Coronaviridae).
infectious bronchitis virus
of chickens, although distinct, groups genetically most closely with SARS-CoV
Swine can host several coronaviruses (hemagglutinating
encephalomyelitis virus, transmissible gastroenteritis virus [TGEV], and
porcine respiratory coronavirus [PRCV]).
Continuous cultures of porcine
turbinate cells (PT-K75) and primary chicken embryo epithelial kidney cells
supported SARS-CoV replication.
|The Army's premier
biological laboratory on Fort Detrick reported two
breaches of containment earlier this
year, leading to the Centers for Disease and Control halting its high-level
The U.S. Army Medical Research Institute of Infectious
Diseases announced Friday that it would restart its operations on a limited
scale. As it works to regain full operational status, more details about the
events leading to the shutdown
An inspection findings report, obtained by the
News-Post through a Freedom of Information Act request, details some of the
observations found during CDC inspections as well as by USAMRIID employees who
reported the issues.
| The date that
PDCoV was introduced into the United States is unknown.
PDCoV samples were from a similar geographic location, the 99.9%100% nt
identity does not correlate with the possible
within the United States.
An alternate hypothesis would
indicate that PDCoV has been an undiagnosed pathogen of pigs in the United
States and, like RVB, has been circulating there for an extended period or that
PDCoV might be a secondary infection to other enteric
Complete genome analysis of the US PDCoV strains
showed that they share 99.9%100% nt identity and a common ancestor with the
only available PDCoV sequences, the China PDCoV strains.
|Few threats to
human health have the potential to cause more impact than emerging zoonoses.
More than half of all known human pathogens have their origins in
It is the threat
posed by these unknown, yet-to-emerge pathogens that requires a
reinvigorated and sustainable pathogen detection network based on One Health
principles to prevent a global widespread pandemic resulting from a zoonotic
|A newly identified
coronavirus that killed nearly 25,000 piglets in 2016-17 in China emerged from
horseshoe bats near the origin of the severe acute respiratory syndrome
coronavirus (SARS-CoV), which emerged in 2002 in the same bat species.
The new virus is named swine acute diarrhea syndrome coronavirus
It does not appear to infect people, unlike SARS-CoV which
infected more than 8,000 people and killed 774.
No SARS-CoV cases have
been identified since 2004.
The study investigators identified SARS-CoV
on four pig farms in Chinas Guangdong Province.
|Ralph Baric, an
infectious-disease researcher at the University of North Carolina at Chapel
Hill, published a study on his team's efforts to engineer a virus with the
surface protein of the SHC014 coronavirus, found in horseshoe bats in China,
and the backbone of one that causes human-like severe acute respiratory
syndrome (SARS) in mice.
The hybrid virus could infect human airway
cells and caused disease in mice, according to the teams results, which were
published in Nature Medicine.
The results demonstrate the ability of
the SHC014 surface protein to bind and infect human cells, validating concerns
that this virusor other coronaviruses found in bat speciesmay be capable of
making the leap to people without first evolving in an intermediate host,
They also reignite a debate about whether that information
justifies the risk of such work, known as gain-of-function research.
the [new] virus escaped, nobody could predict the trajectory, Simon
Wain-Hobson, a virologist at the Pasteur Institute in Paris, told
|The present invention
provides a live, attenuated coronavirus comprising a variant replicase gene
encoding polyproteins comprising a mutation in one or more of non-structural
protein(s) (nsp)-10, nsp-14, nsp-15 or nsp-16.
The coronavirus may be
used as a vaccine for treating and/or preventing a disease, such as infectious
bronchitis, in a subject.
|The simplest way
to judge whether we have an exceptionally lethal disease is to look at the
Are more people dying than we would expect to die anyway
in a given week or month?
Statistically, we would expect about 51,000
to die in Britain this month.
At the time of writing, 422 deaths are
linked to Covid-19 so 0.8 per cent of that expected total.
On a global
basis, wed expect 14 million to die over the first three months of the year.
The worlds 18,944 coronavirus deaths represent 0.14 per cent of that
These figures might shoot up but they are, right now, lower than
other infectious diseases that we live with (such as flu).
that would, in and of themselves, cause drastic global
Initial reported figures from China and Italy suggested a
death rate of 5 per cent to 15 per cent, similar to 1918 Kansas
2010, large-scale outbreaks of diarrhea in suckling piglets have been reported
across China, and vaccination against PEDV has been relatively effective for
However, in February 2017, outbreaks of severe
diarrhea occurred in swine herds vaccinated against PEDV in Guangdong, China.
All ill pigs showed severe watery diarrhea, and their clinical onset
occurred a few days later than those infected with PEDV.
tests with reverse
transcription PCR using specific primers for PEDV, transmissible
gastroenteritis virus, porcine group A rotavirus, or porcine deltacoronavirus,
none of these viruses could be detected.
Academy of Sciences approved the construction of a BSL-4 laboratory in 2003,
and the epidemic of SARS (severe acute respiratory syndrome) around the same
time lent the project momentum.
The lab was designed and constructed with
French assistance as part of a 2004 cooperative agreement on the prevention and
control of emerging infectious diseases.
complexity of the
project, Chinese lack of experience,
difficulty in maintaining
funding and long government approval procedures meant that construction
wasnt finished until the end of 2014.
The SARS virus has escaped from
high-level containment facilities in Beijing multiple times, notes Richard
Ebright, a molecular biologist at Rutgers University in Piscataway, New
in 2017 that a SARS-like virus could escape a lab set up that year in Wuhan,
China, to study some of the most dangerous pathogens in the world.
a SARS-like coronavirus has infected more than 800 there, spread to at least 10
other countries and killed 25 in Wuhan and nearby provinces.
installed the first of a planned five to seven biolabs designed for maximum
safety in Wuhan in 2017, for the purpose of studying the most high-risk
pathogens, including the Ebola and the SARS viruses.
|The news that
COVID-19 bats were under research there means that a leak from the Wuhan
laboratory can no longer be completely ruled out.
A second institute in
the city, the Wuhan Centre for Disease Control which is barely three miles from
the market is also believed to have carried out experiments on animals such as
bats to examine the transmission of coronaviruses.
The Wuhan Institute,
which keeps more than 1,500 strains of deadly viruses, specializes in the
research of 'the most dangerous pathogens', in particular the viruses carried
Chinese officials decided to build the institute after the
country was ravaged by an outbreak of SARS in 2002 and 2003.
another kind of coronavirus, killed 775 people and infected more than 8,000
globally in an epidemic.
enveloped, single-stranded RNA viruses that are distributed worldwide.
They include transmissible gastroenteritis virus (TGEV), porcine
epidemic diarrhea virus (PEDV), and the human coronaviruses severe acute
respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory
syndrome coronavirus (MERS-CoV).
Using a reverse-genetics system based
on CRISPR/Cas9 technology to construct a recombinant TGEV in which this
specific nsp1 motif was altered, we found that this mutation does not affect
virus replication in cell culture but significantly reduces TGEV pathogenicity
Alphacoronaviruses and betacoronaviruses harbor nonstructural
protein 1 (nsp1), which performs multiple functions in inhibiting antiviral
|The present invention pertains to
antigenic peptides of SARS-CoV.
SARS-CoV strain Urbani contains several
peptides recognized by sera derived from individuals which have been and/or are
still infected by SARS-CoV and recognized by control sera derived from
individuals which have not been infected by SARS-CoV.
of a peptide to a serum was calculated as follows.
The average OD-value
for each serum was calculated for the spike protein (sum of OD-values of all
peptides/total number of peptides).
Next, the standard deviation of
this average was calculated.
The standard deviation was multiplied by 2
and the obtained value was added to the average value to obtain the correction
The OD-value of each peptide was then divided by this
If a value of 0.9 or higher was found, then relevant
binding was considered to be present between the specific peptide and the
It is clear for a skilled artisan that parts, variants
or analogues of the peptides and peptides comprising the identified peptides
are also a part of the invention.
|Event 201 pandemic
exercise, conducted on October 18, 2019, vividly demonstrated a number of
important gaps in pandemic preparedness as well as some of the elements of the
solutions between the public and private sectors that will be needed to fill
The Johns Hopkins Center for Health Security, World Economic
Forum, and Bill & Melinda
Gates Foundation jointly propose the following:
|Labs around the
world are turning their sequencing machines, most about the size of a desktop
printer, to the task of rapidly sequencing the genomes of virus samples taken
from people sick with COVID-19.
The information is uploaded to a
website called NextStrain.org that shows how the virus is migrating and
splitting into similar but new subtypes.
|This shows that
there is limited genetic variation in the currently sampled viruses but more
recent ones are showing more divergence as is expected for fast evolving RNA
The lack of diversity is indicative of a relatively recent
common ancestor for all these viruses.
|The model was
created by assembling 3D parts together from related COVID-19 coronavirus
structures available in public databases.
The components used by the
developers include: Spike (S) protein (PDB code 6CRV) Envelope (E) protein (PDB
code 5X29) Membrane (M) protein (PDB code 3I6G).
The distribution of
these proteins on the surface of the virus was aligned by a random algorithm.
The overall representation surface protein density has been reduced to
help show S, E and M proteins.
The M lipid itself was generated using a
particle system to produce a random and organic result.
|Both the reused
and disposable ventilator systems had high bacterial contamination rates after
one week of use.
Disconnection of the ventilator systems should be
avoided during system operation to decrease
the risks of environmental
pollution and human exposure, especially for the disposable ventilator
vaccines are made in living cells (cell substrates). Some manufacturers are
investigating the use of new cell lines to make vaccines.
growth of cell lines ensures that there is a consistent supply of the same
cells that can yield high quantities of the vaccine. In some cases the cell
lines that are used might be tumorigenic, that is, they form tumors when
injected into rodents.
Some of these tumor-forming cell lines may
contain cancer-causing viruses that are not actively reproducing.
viruses are hard to detect using standard methods.
These latent, or
"quiet," viruses pose a potential threat, since they might become active under
vaccine manufacturing conditions.
|Among the myriad
statistics being published every day to
induce the mass panic we're
seeing, one anomaly has been little commented upon.
One of the highest
rates of positive tests for coronavirus in the world, at 3,865 cases per
million of the population, is not Italy, with 1,906, not Spain, with 2,397, and
definitely not the UK, with 497, but Iceland.
With a population of only
340,680 thats only 1,319 cases compared to over 115 thousand in Italy, 112
thousand in Spain, and nearly 34 thousand in the UK; but proportionately,
according to these figures published on various websites recording the daily
spread of the pandemic, Iceland is the worst infected.
|The paper that
appears to have triggered the Trump administration's obsession with
hydroxychloroquine as a treatment for infection with the novel coronavirus has
received a statement of concern from the society that publishes the journal in
which the work appeared.
April 3, 2020: International Journal of
Antimicrobial Agents, states that the March 20 article, Hydroxychloroquine
and azithromycin as a treatment of Covid-19: results of an open-label
non-randomized clinical trial does not meet the [International Society of
Antimicrobial Chemotherapys] expected standard, especially relating to the lack
of better explanations of the inclusion criteria and the triage of patients to
ensure patient safety.
|The decision to
classify government coronavirus preparations in mid-January, followed by the
decision to coordinate the domestic response with the military and with
intelligence deserves considerable scrutiny, particularly given that at least
one federal agency, Customs and Border Patrol (CBP), will be given broad,
sweeping powers and will work closely with unspecified intelligence "partners"
as part of its response to a pandemics like COVID-19.
While the plans of
the federal government remain classified,
recent reports have
revealed that the military and intelligence communities now working with
the NSC to develop the governments coronavirus response have anticipated a
massive explosion in cases for weeks.
US military intelligence came to
the conclusion in early February that coronavirus cases would reach pandemic
proportions domestically by the end of March.
The National Center for
Medical Intelligence (NCMI), coordinates closely with the National Security
Agency (NSA) to conduct medical SIGINT [signals intelligence].
|Tony Fauci, a
leading member of the White House Coronavirus Task Force, is being promoted by
major US media such as CNN, MSNBC or the
New York Times as the great
expert on all related to the Covid19 outbreak.
Tony Fauci has held the
top post at the NIAID in Washington for an astonishing 36 years.
1984 Robert Gallo, working under Fauci, falsely announced that he had
"discovered" the AIDS virus.
Media was told that AIDS was the "public
health threat of the Century."
Gallo went on to make millions on his
patented blood test for HIV, despite the fact that the test was often giving
false positives and did not test directly for the alleged virus but for active
antibodies, something immunology practice said was not valid, as antibodies
merely suggested a past infection response and not necessarily presence of
|Researchers are employing
a multifaceted approach to the creation of a potential AIDS vaccine.
These approaches include the use of killed or attenuated virus,
purified natural or synthetic subunits of the virus, infectious recombinant
viruses, and anti-idiotypes.
The first clinical trial of a subunit AIDS
vaccine began in September 1987 at the National Institutes of Health (NIH).
|Even before you
know something works, at risk, you have to start producing it.
know it works, you can't say, it works, give me another six months.
are working with a variety of companies to take that risk.
take it with zika.
Same with sars.
That is what we are going to
push on is to be able to have it ready if, in fact, it works. the issue of
safety, something I want to make sure the American public understands.
There is safety associated, does the vaccine make you
There are diseases in which you vaccinate and get infected and
enhance the infection.
antiretroviral treatment and current prevention options have considerably
reduced HIV infections and
AIDS-related deaths, a safe and effective vaccine
is needed to end the global AIDS pandemic expeditiously and sustainably,
according to a new commentary from Anthony S. Fauci, M.D., Director of the
National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S.
National Institutes of Health (NIH), and colleague Hilary D. Marston, M.D.,
M.P.H., in New England
Journal of Medicine.
World Health Organization designated the
coronavirus a pandemic extraordinary privileges were conferred to
Trump announced a ban for the next 30 days on travelers flying from Europe to
the United States.
The document states: Due to the distance from CDC
Quarantine Stations, some [CBP] locations will require areas designated for
medical segregation to safely detain travelers potentially infected with the
pandemic flu virus, thereby, helping prevent the spread of the virus to other
detainees, travelers, and
And: CBP Directors of Field Operations and Chief Patrol Agents will
jointly inventory their detention and
isolation facilities, and identify other areas that may be utilized for
these purposes, e.g., tent cities with portable latrines.
|This July, we will
be celebrating the centennial anniversary of London's First International
Eugenics Conference of 1912.
One century later, on July 11, 2012,
the Bill & Melinda Gates Foundation
(the largest private foundation in the world) and the British government will
co-host a new London conference on eugenics with global coalition partners such
as American abortion chain Planned Parenthood, British abortion chain Marie
Stopes International, and the United Nations Populations Fund (UNFPA).
The only difference is that the July 2012 London conference will never
acknowledge that eugenics is its driving idea.
Hard eugenics is the ideology that dare
not speak its name.
Soft eugenics is based on the same disturbing
belief -- that government should spend its resources to prevent the propagation
of those whom the government believes to be detrimental to society and economic
efforts are a concern because apparently the only thing she and her partners
intend to cure with this campaign is pregnancy, which is not a disease.
One cant help but wonder what the $4.6 billion they already have raised
could do to bring effective medical care closer to those who need it rather
than simply preventing our children from being born.
hopefully realise that letting rich people decide on population size is a bad
coronavirus pneumonia (COVID-19) is an infectious acute respiratory infection
caused by the novel coronavirus.
The virus is a positive-strand RNA
virus with high homology to bat coronavirus.
In this study, conserved
domain analysis, homology modeling, and molecular docking were used to compare
the biological roles of certain proteins of the novel coronavirus.
results showed the ORF8 and surface glycoprotein could bind
to the porphyrin, respectively.
At the same time, orf1ab, ORF10, and
ORF3a proteins could coordinate attack the heme on the 1-beta chain of
hemoglobin to dissociate the
iron to form the porphyrin.
The attack will cause less and less
hemoglobin that can carry oxygen and carbon dioxide.
The lung cells
have extremely intense poisoning and inflammatory due to the inability to
exchange carbon dioxide and oxygen frequently, which eventually results in
ground-glass-like lung images.
patient age was 63 years old.
The mortality rate for all patients placed
on mechanical ventilation was 88.1%.
The case series documents
comorbidities among patients, with the most common being hypertension,
Almost 42 percent
of all patients hospitalized with coronavirus were reportedly obese, with a
body mass index (BMI) of more than or at 30.
Diabetes was found to be a
prevalent pre existing condition, with 33.8 percent of coronavirus patients
reported as being diabetic.
Damages: Fraud and Wrongful Death."
Filed suit against multiple
defendants including Life Care Centers of America, Inc.
The other named
defendants include Lake Vue Operations, LLC, LCCAs Vice President of Operations
West, and Kirklands Executive Director.
The suit was filed in the King
County Superior Court of Washington on April 10, 2020.
On April 13,
2020, CMS released guidance highlighting the flexibilities regarding patient
Transfers may be necessary to separate residents based on
whether they have tested positive or are otherwise suspected of having
When transfers are to be made to non-certified facilities,
State Agency approval is required.
COVID-19 Preparedness Checklist for Nursing
|UPDATE, April 28:
Here is a link to the most recent data for total deaths in the U.S. by week,
rather than by month, from the CDC.
The most recent week for which they
are reporting complete data is what they call 2020 Week 15, which appears to be
the week of April 5 to 11.
They report 55,905 total deaths that week.
If the normal number of non-coronavirus deaths per day in April is
7700, that would mean that a normal non-coronavirus week would be
So the number of excess deaths in
that week is about 2000.
Worldometers reports the number of
Covid-19 deaths that week as 13,678.
prevalence of SARS-CoV-2 antibodies in Santa Clara County implies that the
infection is much more widespread than indicated by the number of confirmed
Population prevalence estimates can now be used to calibrate
epidemic and mortality projections.
people in America weeks earlier than first thought, according to a new report
citing confirmation from the Centers for Disease Control and Prevention.
The first two deaths occurred on Feb. 6 and 17 in Santa Clara County,
California a tech hub that had previously considered March 9 its first death
death date the countys health department said in a statement late Tuesday.
This means the virus was introduced and circulating in our community
far earlier than we had previously known, said Dr. Sara Cody, director of
public health for Santa Clara County, during a briefing on Wednesday morning.
There was likely a significant level of the virus circulating in early
February and probably late January.
| Apr 8, 2020: With
over two dozen different molecular diagnostics now authorized by the FDA for
COVID-19, the field is beginning to see the first of a new group of tests aimed
at screening for people's immune responses to the disease and cataloguing past
infections instead of active ones.
While overall testing capacity of
any kind remains far short of meeting demand, antibody blood tests would
provide additional data on the spread of the novel coronavirus, and results
showing immunity could be used to give people an all-clear to leave quarantine
and return to work. Their accuracy would, of course, have to be paramountany
false positives could send unprotected people back into harms way.
researchers at the University of Oxford tasked with evaluating these
serological tests say theyre still weeks away from solid validation and that no
versions to date have performed well.
suspect the driving force in many gravely ill patients' downhill trajectories
is a disastrous overreaction of the
immune system known as a "cytokine storm," which other
viral infections are known to trigger.
Cytokines are chemical signaling
molecules that guide a healthy immune response; but in
a cytokine storm, levels of
certain cytokines soar far beyond whats needed, and immune cells start to
attack healthy tissues.
Blood vessels leak, blood pressure drops, clots
form, and catastrophic organ failure can ensue. Some studies have shown
elevated levels of these inflammation-inducing cytokines in the blood of
hospitalized COVID-19 patients.
The real morbidity and mortality of
this disease is probably driven by this out of proportion inflammatory response
to the virus, says Jamie Garfield, a pulmonologist who cares for COVID-19
patients at Temple University Hospital.
|A new study in
China has found that the novel coronavirus has mutated into at least 30
showed that medical officials have vastly underestimated the overall ability of
the virus to mutate, in findings that different strains have affected different
parts of the world, leading to potential difficulties in finding an overall
World Health Organization issued a warning
Friday about coronavirus testing, saying there's no evidence serological tests
can show whether a person has immunity or is no longer at risk of becoming
These antibody tests will be able to measure that level of
serology presence, that level of antibodies, but that does not mean that
somebody with antibodies is immune, said Dr. Maria Van Kerkhove, head of WHOs
emerging diseases and zoonosis unit.
respirators do not work.
There have been extensive randomized
controlled trial (RCT) studies, and meta-analysis reviews of RCT studies, which
all show that masks and respirators do not work to prevent respiratory
influenza-like illnesses, or respiratory illnesses believed to be transmitted
by droplets and aerosol particles.
Furthermore, the relevant known
physics and biology, which I review, are such that masks and respirators should
be a paradox if masks and respirators worked, given what we know about
viral respiratory diseases: The main transmission path is long-residence-time
aerosol particles (< 2.5 µm), which are too fine to be blocked, and
the minimum-infective-dose is smaller than one aerosol particle.
present paper about masks illustrates the degree to which governments, the
mainstream media, and institutional propagandists can decide to operate in a
science vacuum, or select only incomplete science that serves their interests.
is also certainly the case with the current global lockdown of over 1 billion
people, an unprecedented experiment in medical and political
presidency of George H.W. Bush in the early 1990s, something disturbing
unfolded at the U.S.' top biological warfare research facility at Fort Detrick,
Maryland. Specimens of highly contagious and deadly pathogens anthrax
and ebola among them had disappeared from the lab, at a time when lab
workers and rival scientists had been accused of targeted sexual and ethnic
harassment and several disgruntled researchers had left as a result.
internal Army inquiry in 1992 would reveal that one employee,
Lt. Col. Philip Zack, had been caught
on camera secretly entering the lab to conduct unauthorized research,
apparently involving anthrax, the Hartford Courant would later report.
Despite this, Zack would continue to do infectious disease research for
pharmaceutical giant Eli Lilly and would collaborate with the U.S. National
Institute of Allergy and Infectious Disease (NIAID) throughout the 1990s.
|One hundred forty
six homeless persons at a Boston shelter tested positive for the coronavirus
without showing any symptoms, concerning experts that the pandemic may be more
wide spread than originally thought.
The Pine Street Inn was following
up a small cluster of cases last week and tested 397 people to discover that
146 were confirmed to have the deadly flu-like virus, also known as COVID-19.
What was equally alarming to health officials was also learning that
100 per cent of the confirmed cases at the shelter had no symptoms.
surveillance firm founded by conservative billionaire Peter Thiel, has landed a
contract with the feds to build a database tracking the spread of the novel
coronavirus around the country.
Palantir data products will be primary,
or even core, to a Health and Human Services project called Protect Now and
will pull data from federal, state, and local governments, as well as
universities and medical facilities.
The purpose of the project is to
mitigate and prevent spread of the virus, an HHS spokesperson told the site.
Palantirs involvement is likely to raise eyebrows, as Thiel is both its
chairman and a prominent Donald Trump supporter who has pledged to support the
presidents re-election campaign.
He also reportedly was involved in
pushing Facebook, where he holds a board seat, to allow political lies in ads,
even setting up a meeting between Mark Zuckerberg and Trump at the White
Palantir, Prism, Facebook & The Industrial Surveillance
We have seen this kind of intense pressure on Aaron Swartz.
Immediately the story was no longer about government surveillance and
potential crimes but about 'crazy ol' Brown'.
Brown has been
sitting in jail
ever since and the story was dropped until Snowden came along.
practices at the Centers for Disease Control and Prevention caused
contamination that rendered the nation's first coronavirus tests ineffective,
federal officials confirmed on Saturday.
Two of the three CDC
laboratories in Atlanta that created the coronavirus test kits violated their
own manufacturing standards.
CDC sent tests that did not work to nearly
all of the 100 state and local public health labs, according to the Food and
coronavirus testing expands in prisons, large numbers of inmates are showing no
symptoms. In four state prison systems Arkansas, North Carolina, Ohio
and Virginia 96% of 3,277 inmates who tested positive for the
coronavirus were asymptomatic, according to interviews with officials and
records reviewed by Reuters.
Thats out of 4,693 tests that included results on symptoms.
trial in children showed that flu shots increased fivefold the risk of
acute respiratory infections caused by a group of noninfluenza viruses,
|There is genetic
evidence suggestive of human tinkering in the genome, and there are news
stories suggesting the virus might have been developed either at the Wuhan
Institute of Virology or at the American virology lab at Fort Detrick.
There are even some suggestions that the American and Chinese
bioweapons labs may be working together, sharing samples and exchanging
The question of a laboratory origin for COVID is politically
explosive, so we expect a heavy
hand restraining the science establishment.
Those of us seeking an
honest answer, who have a little expertise, a little horse sense, and a lot of
patience, are left to sift through information, misinformation, and
disinformation in a politicized environment.
| 2014 The Lugar
Center, a $161 million Pentagon-funded biolaboratory in Georgia's capital
Tbilisi, discovered coronaviruses in bats with presumably pandemic
2016 Eco Health Alliance, US scientists and
the The Global Virome Project
2018 Pentagon launched a $2.9 million
program at the Lugar Center involving genetic studies on coronaviruses in 5,000
bats collected in Western Asia.
Eco Health Alliance received a $3.7
million grant from the US National Institute of Health (NIH) to collect and
study coronaviruses in bats in China from 2014 to 2019.
coronaviruses were similar to beta coronaviruses discovered in bats in
Spain, Italy, Bulgaria
and to the pandemic SARS coronavirus with lethal outcome in Amsterdam, China,
Florida and Colorado.
US Defense Threat Reduction Agency (DTRA) launches
a $2.9 million project on bats and coronaviruses in Western Asia with the Lugar
Center being the local laboratory for this genetic research.
duration of the program is 5 years and has been implemented by the non-profit
US organization Eco Health Alliance.
The Rockefeller Foundation has long
been supporting such projects.
The foundation has even provided the
dangerous Zika Virus for sale online for research purposes.
the project was presented at the Rockefeller Foundations Conference Center in
Bellagio, Italy which 4 years later became the epicenter of the coronavirus
pandemic in Europe.
| We present an
approach to encode medical history on a patient using the spatial distribution
of biocompatible, near-infrared quantum dots (NIR QDs) in the dermis.
QDs are invisible to the naked eye yet detectable when exposed to NIR
QDs with a copper indium selenide core and aluminum-doped zinc
sulfide shell were tuned to emit in the NIR spectrum by controlling
stoichiometry and shelling time.
The formulation showing the greatest
resistance to photobleaching after simulated sunlight exposure (5-year
equivalence) through pigmented human skin was encapsulated in microparticles
for use in vivo.
|In response to the
COVID-19 pandemic, QDX HealthID provides end-to-end visibility to support
testing and immunization, including authentication of patients, healthcare
providers and virus test kits.
search for a vaccine that can stop the AIDS virus has delivered yet another
The HIV vaccine that had moved furthest along in
human testing does not work, and the $104 million trial in
South Africa evaluating
it has been stopped early.
Theres absolutely no evidence of efficacy,
says Glenda Gray, who heads the study and is president of the South African
Medical Research Council (MRC).
Years of work went into this. Its a
|Using history as a
lens, it is possible to look at the current coronavirus crisis to see how the
long-standing agendas of ever-expanding mass surveillance and media censorship
are again getting a dramatic boost thanks to the chaos unleashed by the
Pentagons Defense Advanced Research Projects
Agency (DARPA) has remained largely out of sight and
out of mind for most
Americans, as their research projects are rarely covered by the mainstream
media and, when they are, their projects are often praised as
bringing science fiction movies to life.
|"There is a lot of
speculation here. They have no experimental verification," Peter Hotez, PhD, of
the Texas Children's Hospital Center for Vaccine Development in Houston, told
the Los Angeles
In any case, as the investigators themselves noted,
increased transmissibility does not necessarily imply increased danger; a
sub-analysis in the report showed no rise in the risk of severe illness linked
to the mutated sequence, compared with its predecessor:
evidence of recombination between locally circulating strains, indicative of
multiple strain infections.
The mutation Spike D614G is of urgent
concern; it began spreading in Europe in early February, and when introduced to
new regions it rapidly becomes the dominant form.
Given Spikes vital
importance both in terms of viral infectivity and as an antibody target, we
felt an urgent need for an early warning pipeline to evaluate Spike pandemic
Our primary intent is to identify dynamically changing
patterns of mutation indicative of positive selection for Spike variants.
Also, because recombination is an important aspect of coronavirus
evolution (Graham and Baric, 2010; Li et al., 2020; Rehman et al., 2020), we
also set out to determine if whether recombination is playing a role in
SARS-CoV-2 pandemic evolution.
chronicle a three-stage
data pipeline (analysis of daily GISAID data, structural modeling of sites of
interest, and experimental evaluation) and the identification of several sites
of positive selection, including one (D614G) that may have originated either in
China or Europe, but begin to spread rapidly first in Europe, and then in other
parts of the world, and which is now the dominant pandemic form in many
Over 62 vaccine approaches are currently being explored, and
a wide variety of candidate SARS-CoV-2 vaccines are in
|Most of this
manuscript focuses on a particular mutant called D614G.
outside the field, thats a standard notation that translates as at
amino acid residue 614, take the
existing amino acid (aspartic acid,
single-letter code D) and change it to a glycine (single-letter code G)
That change happens through the triplet code in the RNA sequence that
codes for the amino acids a single
random-mutation A-to-G switch in the right spot is enough to flip the resulting
amino acid from an aspartate to
a glycine (GAU and GAC both code for aspartic acid, and GGU and GGC both code
Those are pretty different beasts: aspartic acid has a
polar, charged side chain, while
glycine is the
Sheffield group was able to match up hospitalization data with the
sequencing of 453 individual patients, and they found no correlation of
hospitalization status with the
Trevor Bedford and the UW group independently checked for this and had
the same result: no apparent effect on severity of disease.
has empirically shown the malleable and dreamlike nature of our universe.
The mutability of the universewhich quantum physics has discovered to
be one of the primary aspects of nature, not to mention of our mindsimplies
that nothing is absolute, nothing is so fundamental (particularly our state of
consciousness) that it cannot change under certain circumstances.
that we've collectively
dreamed up our current situation, when enough of us wake up to the
dreamlike nature of our world and the role our consciousness plays each moment
in giving it shape and form we can, in theory and hopefully in practice,
discover that we can dream it differently.
In other words, when we
realize that we actually have a hand in creating something that isnt serving
us, it is within the realm
of possibility and within our power to un-create it, thereby changing the
collectively shared waking dream we are having.
medical interventions, including vaccines, have risks and benefits," stated
Association of American Physicians and Surgeons executive director, Jane
M. Orient, M.D.
Physicians have the duty to advise patients according
to their own best judgment, and patients have the right to decline to follow
Patients also have the right to be fully informed and not
restricted to governmentally approved information.
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industrial military entertainment complex and is responsible for the collapse
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corporate media psychological operations. The results have been the destruction
of the family and the destruction of social structures that do not adhere to
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